Jeffery D Molkentin Selected Research

Cardiomegaly (Heart Hypertrophy)

12/2018	Myofibroblast-Specific TGFβ Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy.
6/2017	Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart.
12/2016	Regulation of cardiac hypertrophy and remodeling through the dual-specificity MAPK phosphatases (DUSPs).
10/2016	Inositol 1,4,5-trisphosphate-mediated sarcoplasmic reticulum-mitochondrial crosstalk influences adenosine triphosphate production via mitochondrial Ca2+ uptake through the mitochondrial ryanodine receptor in cardiac myocytes.
11/2015	TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB, and Bnip3 Pathways.
10/2014	RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis.
7/2014	Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition.
1/2014	Overexpression of the Na+/K+ ATPase α2 but not α1 isoform attenuates pathological cardiac hypertrophy and remodeling.
6/2013	Parsing good versus bad signaling pathways in the heart: role of calcineurin-nuclear factor of activated T-cells.
4/2013	Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Jeffery D Molkentin Research Topics

Disease

53	Cardiomegaly (Heart Hypertrophy) 12/2018 - 03/2002
52	Hypertrophy 10/2021 - 03/2002
42	Heart Failure 01/2022 - 04/2002
29	Fibrosis (Cirrhosis) 12/2018 - 04/2002
18	Cardiomyopathies (Cardiomyopathy) 01/2019 - 02/2003
16	Necrosis 05/2016 - 03/2005
15	Myocardial Infarction 01/2018 - 01/2004
14	Heart Diseases (Heart Disease) 11/2017 - 03/2002
14	Muscular Dystrophies (Muscular Dystrophy) 05/2016 - 06/2006
12	Ischemia 01/2020 - 01/2004
9	Reperfusion Injury 01/2021 - 01/2004
9	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 01/2017 - 03/2004
8	Infarction (Infarctions) 04/2014 - 04/2004
6	Body Weight (Weight, Body) 01/2021 - 04/2002
6	Rupture 01/2020 - 08/2013
6	Inflammation (Inflammations) 10/2017 - 04/2005
5	Ventricular Remodeling 01/2018 - 08/2007
5	Neoplasms (Cancer) 01/2012 - 07/2002
5	Infections 03/2011 - 03/2002
4	Sudden Death 01/2017 - 09/2003
4	Pancreatitis 01/2016 - 04/2012
4	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 01/2011 - 06/2006
3	Atrophy 01/2021 - 01/2010
3	Cardiac Arrhythmias (Arrythmia) 01/2020 - 09/2003
3	Cicatrix (Scar) 01/2018 - 01/2016
3	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 05/2016 - 03/2007
3	Thrombosis (Thrombus) 07/2010 - 02/2008
2	Insulin Resistance 11/2020 - 02/2013
2	Type 2 Diabetes Mellitus (MODY) 11/2020 - 02/2010
2	Hyperglycemia 01/2020 - 02/2010
2	Pulmonary Hypertension 12/2019 - 05/2003
2	Fatigue 11/2018 - 04/2015

Drug/Important Bio-Agent (IBA)

52	CalcineurinIBA 11/2015 - 03/2002
31	Proteins (Proteins, Gene)FDA Link 01/2020 - 04/2002
18	CalciumIBA 05/2016 - 03/2002
16	Transcription Factors (Transcription Factor)IBA 01/2020 - 08/2002
12	Mitochondrial Permeability Transition PoreIBA 01/2021 - 09/2007
12	Protein Isoforms (Isoforms)IBA 01/2015 - 12/2002
11	Cyclophilins (Cyclophilin)IBA 01/2021 - 03/2005
8	Mitogen-Activated Protein KinasesIBA 11/2020 - 04/2004
8	Phosphotransferases (Kinase)IBA 01/2020 - 11/2002
8	Phosphoric Monoester Hydrolases (Phosphatases)IBA 12/2019 - 03/2002
8	PeriostinIBA 01/2017 - 08/2007
7	CytokinesIBA 10/2018 - 04/2005
7	Sarcoglycans (beta Sarcoglycan)IBA 12/2014 - 06/2006
6	CollagenIBA 01/2021 - 02/2009
6	Angiotensin IIIBA 11/2020 - 11/2002
6	DNA (Deoxyribonucleic Acid)IBA 12/2019 - 01/2004
6	DystrophinIBA 05/2016 - 01/2007
6	Protein Kinases (Protein Kinase)IBA 01/2015 - 08/2006
6	Transforming Growth Factors (Transforming Growth Factor)IBA 12/2014 - 02/2011
6	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2012 - 05/2003
6	Cyclosporine (Ciclosporin)FDA LinkGeneric 02/2011 - 04/2002
6	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 02/2009 - 01/2004
5	Calmodulin (Calcium-Dependent Activator Protein)IBA 01/2020 - 05/2002
5	Protein Kinase CIBA 01/2018 - 02/2007
5	p38 Mitogen-Activated Protein KinasesIBA 08/2017 - 05/2003
5	LuciferasesIBA 09/2015 - 05/2003
5	Histone Deacetylases (Histone Deacetylase)IBA 04/2013 - 03/2006
4	RNA (Ribonucleic Acid)IBA 10/2021 - 11/2017
4	Messenger RNA (mRNA)IBA 01/2020 - 02/2006
4	DesminIBA 10/2018 - 12/2010
4	Tamoxifen FDA LinkGeneric 01/2017 - 02/2005
4	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2016 - 11/2002
4	MyostatinIBA 01/2016 - 06/2006
4	Adenosine Triphosphate (ATP)IBA 01/2016 - 03/2008
4	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2016 - 02/2008
4	Tacrolimus (Prograf)FDA LinkGeneric 09/2015 - 03/2002
4	Calcineurin InhibitorsIBA 09/2015 - 03/2002
4	Peptides (Polypeptides)IBA 10/2011 - 02/2006
4	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 07/2011 - 05/2003
4	cysteine and glycine-rich protein 3IBA 08/2006 - 03/2004
3	Complementary DNA (cDNA)IBA 01/2021 - 02/2003
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 03/2011
3	IntegrinsIBA 01/2019 - 08/2010
3	Transforming Growth Factor beta (TGF-beta)IBA 10/2018 - 02/2006
3	Crystallins (Crystallin)IBA 10/2018 - 09/2014
3	ruboxistaurinIBA 12/2017 - 07/2009
3	Creatine Kinase (Creatine Phosphokinase)IBA 03/2016 - 03/2011
3	ChemokinesIBA 01/2016 - 04/2005
3	Pharmaceutical PreparationsIBA 01/2016 - 02/2009
3	Adenosine Triphosphatases (ATPase)IBA 01/2015 - 04/2009
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 02/2013 - 11/2002
3	Insulin (Novolin)FDA Link 01/2013 - 01/2004
3	Serine (L-Serine)FDA Link 07/2011 - 10/2004
3	salicylhydroxamic acid (SHAM)IBA 02/2011 - 08/2007
3	transcription factor NF-AT c3IBA 10/2008 - 06/2003
2	Dual-Specificity PhosphatasesIBA 11/2020 - 04/2004
2	Glucose (Dextrose)FDA LinkGeneric 11/2020 - 02/2011
2	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2020 - 03/2006
2	Transforming Growth Factor-beta Type II ReceptorIBA 12/2018 - 10/2018
2	Carrier Proteins (Binding Protein)IBA 12/2018 - 01/2016
2	Extracellular Matrix ProteinsIBA 01/2018 - 01/2009
2	Glycoproteins (Glycoprotein)IBA 01/2018 - 03/2016
2	Fibronectins (Fibronectin)IBA 01/2018 - 01/2012
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 08/2017 - 10/2014
2	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2016 - 06/2011
2	Bile Acids and Salts (Bile Acids)IBA 01/2016 - 01/2013
2	Enzyme Precursors (Zymogens)IBA 01/2016 - 04/2012

Therapy/Procedure

6	Therapeutics 01/2021 - 05/2004